The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …

The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a
heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac …

Transient receptor potential (TRP) channels are nonselective cationic channels that are
generally Ca2+ permeable and have a heterogeneous expression in the heart. In the …

Zn2+, Mg2+, and Ca2+ are essential minerals required for a plethora of metabolic processes
and signaling pathways. Different categories of cation-selective channels and transporters …

TRPM7 is a ubiquitous ion channel and kinase, a unique" chanzyme," required for proper
early embryonic development. It conducts Zn 2+, Mg 2+, and Ca 2+ as well as monovalent …

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 …

Mg2+ regulates many physiological processes and signalling pathways. However, little is
known about the mechanisms underlying the organismal balance of Mg2+. Capitalizing on a …

Magnesium is essential for cellular life, but how it is homeostatically controlled still remains
poorly understood. Here, we report that members of CNNM family, which have been …