Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane
of metazoan cells that represent sites of attachment to—and degradation of—the …

The metastatic process, ie the dissemination of cancer cells throughout the body to seed
secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

When migrating away from a primary tumour, cancer cells interact with and remodel the
extracellular matrix (ECM). Matrix metalloproteinases (MMPs), and in particular the …

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based
on 3D migration models has revealed a diversity of invasive migratory schemes reflecting …

All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …

Podosomes and invadopodia, collectively known as invadosomes, are cell-matrix contacts
in a variety of cell types, such as monocytic cells or cancer cells, that have to cross tissue …

The invasiveness of cells is correlated with the presence of dynamic actin-rich membrane
structures called invadopodia, which are membrane protrusions that are associated with …

Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells. The
mechanisms regulating invadopodium assembly and maturation are not understood. We …