Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked
to Parkinson's disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post …

Abstract Purpose of Review Genetic variants in GBA1 and LRRK2 genes are the commonest
genetic risk factor for Parkinson disease (PD); however, the preclinical profile of GBA1 and …

Molecular chaperones are the guardians of the proteome inside the cell. Chaperones
recognize and bind unfolded or misfolded substrates, thereby preventing further …

DNAJB6 is a prime example of an anti‐aggregation chaperone that functions as an
oligomer. DNAJB6 oligomers are dynamic and subunit exchange is critical for inhibiting …

Background Genetic factors play a crucial role in the pathogenesis of Parkinson's disease
(PD). However, no comprehensive study has described genetic alterations in Vietnamese …

Long-read sequencing has been shown to have advantages in structural variation (SV)
detection and methylation calling. Many studies focus either on SV, methylation, or phasing …

The DNAJB6 chaperone inhibits fibril formation of aggregation-prone client peptides through
interaction with aggregated and oligomeric forms of the amyloid peptides. Here, we studied …

Anderson–Fabry disease (AFD) is an inherited lysosomal storage disorder characterized by
a composite and multisystemic clinical phenotype and frequent involvement of the central …

Anderson–Fabry disease (AFD) is a genetic sphingolipidosis involving virtually the entire
body. Among its manifestation, the involvement of the central and peripheral nervous system …

Despite implementation of enhanced management practices, chronic wasting disease in US
white-tailed deer (Odocoileus virginianus) continues to expand geographically. Herein, we …