The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Although the medical definition of itch has been in existence for 360 years, only in the last 20
years have we begun to understand the basic mechanisms that underlie this unique …

Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and
noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory …

Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …

The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized to a subpopulation of primary sensory neurons of the …

Allergic contact dermatitis is a common skin disease associated with inflammation and
persistent pruritus. Transient receptor potential (TRP) ion channels in skin-innervating …

Growing evidence supports the pivotal role played by oxidative stress in tissue injury
development, thus resulting in several pathologies including cardiovascular, renal …

Itch is an unpleasant cutaneous sensation that can arise following insect bites, exposure to
plant ingredients, and some diseases. Itch can also have idiopathic causes. Itch sensations …