The field of Traditional Chinese Medicine (TCM) represents a vast and largely untapped
resource for modern medicine. Exemplified by the success of the antimalarial artemisinin …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Cells chemically isolate molecules in compartments to both facilitate and regulate their
interactions. In addition to membrane-encapsulated compartments, cells can form …

Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide
interest because it shows substantial anticancer activity in patients with acute promyelocytic …

Nuclear architecture—the spatial arrangement of chromosomes and other nuclear
components—provides a framework for organizing and regulating the diverse functional …

The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear
body (PML-NB) and is crucially required for the proper assembly of this macromolecular …

MicroRNAs play important roles in cell differentiation by acting as translational inhibitors of
specific target genes. Here we show that human granulocytic differentiation is controlled by …

The yeast Sir2 protein mediates chromatin silencing through an intrinsic NAD‐dependent
histone deacetylase activity. Sir2 is a conserved protein and was recently shown to regulate …

In recent years, great progress has been made in elucidating the progenitor-cell hierarchy of
the myeloid lineage. Transcription factors have been shown to be key determinants in the …

Our forefathers in pathology, on observing cancer tissue under the microscope in the mid-
19th century, noticed the similarity between embryonic tissue and cancer, and suggested …