The zebrafish has proven to be an excellent model for analyzing issues of vertebrate
development. In this review we ask whether the zebrafish is a viable model for analyzing the …

The zebrafish is an especially attractive model for the study of the development and function
of the vertebrate inner ear. It combines rapid and accessible embryogenesis with a host of …

Much progress has been made toward generating analogs of early embryos, such as
gastruloids and embryoids, in vitro. However, methods for how to fully mimic the cell …

Normal growth and development depends upon high fidelity regulation of cap-dependent
translation initiation, a process that is usurped and redirected in cancer to mediate …

We report an analysis of forebrain determination and patterning in the zebrafish Danio rerio.
In order to study these events, we isolated zebrafish homologs of two neural markers, odd …

Publisher Summary Three approaches have been used successfully to clone genes defined
by mutations in zebrafish: retroviral tagging, testing candidate genes, and positional cloning …

The neuroectoderm of the vertebrate gastrula was proposed by Nieuwkoop to be
regionalized into forebrain, midbrain, hindbrain and spinal cord by a two-step process. In the …

Evolutionary conservation and experimental tractability have made animal model systems
invaluable tools in our quest to understand human embryogenesis, both normal and …

Following fertilization of many animal embryos, rapid synchronous cleavage divisions give
way to longer, asynchronous cell cycles at the midblastula transition (MBT). The cell cycle …

Owing to its optical clarity and rapid rate of development, the zebrafish embryo is an ideal
model system for studying the cellular mechanics of organogenesis. Unfortunately, extended …