Consensus paper: cerebellum and social cognition

F Van Overwalle, M Manto, Z Cattaneo, S Clausi… - The Cerebellum, 2020 - Springer
The traditional view on the cerebellum is that it controls motor behavior. Although recent
work has revealed that the cerebellum supports also nonmotor functions such as cognition …

Big data approaches to decomposing heterogeneity across the autism spectrum

MV Lombardo, MC Lai, S Baron-Cohen - Molecular psychiatry, 2019 - nature.com
Autism is a diagnostic label based on behavior. While the diagnostic criteria attempt to
maximize clinical consensus, it also masks a wide degree of heterogeneity between and …

Cerebellar modulation of the reward circuitry and social behavior

I Carta, CH Chen, AL Schott, S Dorizan, K Khodakhah - Science, 2019 - science.org
INTRODUCTION Although the cerebellum has long been considered to be a purely motor
structure, recent studies have revealed that it also has critical nonmotor functions. Cerebellar …

Advancing the understanding of autism disease mechanisms through genetics

L de la Torre-Ubieta, H Won, JL Stein… - Nature medicine, 2016 - nature.com
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …

Neurobiology of rodent self-grooming and its value for translational neuroscience

AV Kalueff, AM Stewart, C Song, KC Berridge… - Nature Reviews …, 2016 - nature.com
Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing
pattern and is one of the most frequently performed behavioural activities in rodents. In this …

Emerging connections between cerebellar development, behaviour and complex brain disorders

A Sathyanesan, J Zhou, J Scafidi, DH Heck… - Nature Reviews …, 2019 - nature.com
The human cerebellum has a protracted developmental timeline compared with the
neocortex, expanding the window of vulnerability to neurological disorders. As the …

Cerebro-cerebellar circuits in autism spectrum disorder

AM D'Mello, CJ Stoodley - Frontiers in neuroscience, 2015 - frontiersin.org
The cerebellum is one of the most consistent sites of abnormality in autism spectrum
disorder (ASD) and cerebellar damage is associated with an increased risk of ASD …

Neurobiological bases of autism–epilepsy comorbidity: a focus on excitation/inhibition imbalance

Y Bozzi, G Provenzano… - European Journal of …, 2018 - Wiley Online Library
Autism spectrum disorders (ASD) and epilepsy are common neurological diseases of
childhood, with an estimated incidence of approximately 0.5–1% of the worldwide …

Large-scale analyses of the relationship between sex, age and intelligence quotient heterogeneity and cortical morphometry in autism spectrum disorder

SA Bedford, MTM Park, GA Devenyi, S Tullo… - Molecular …, 2020 - nature.com
Significant heterogeneity across aetiologies, neurobiology and clinical phenotypes have
been observed in individuals with autism spectrum disorder (ASD). Neuroimaging-based …

Germline Chd8 haploinsufficiency alters brain development in mouse

AL Gompers, L Su-Feher, J Ellegood, NA Copping… - Nature …, 2017 - nature.com
The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental
gene networks implicated in autism. We examined the impact of germline heterozygous …