Cellular ROS production participates in various cellular functions but its accumulation
decides the cell fate. Malignant cells have higher levels of ROS and active antioxidant …

Previous studies have shown that mitochondria play core roles in not only cancer stem cell
(CSC) metabolism but also the regulation of CSC stemness maintenance and differentiation …

Like living organisms, cancer cells require energy to survive and interact with their
environment. Mitochondria are the main organelles for energy production and cellular …

Circular RNA (CircRNA) is a newly identified special class of non-coding RNA (ncRNA) that
plays an important regulatory role in the progression of certain diseases. Herein, our results …

Metastatic hepatocellular carcinoma (HC) is a serious health concern. The stemness of
cancer stem cells (CSCs) is a key driver for HC tumorigenesis, apoptotic resistance, and …

Mitochondria are known as essential biosynthetic, bioenergetic and signaling organelles,
and play a critical role in cell differentiation, proliferation, and death. Nowadays, cancer is …

Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and is recognized
as a major contributor to cancer-related mortality worldwide. Cancer stem cells (CSCs) are a …

Mitophagy, a form of autophagy, plays a role in cancer development, progression and
recurrence. Cancer stem cells (CSCs) also play a key role in these processes, although it …

Mitochondria are essential organelles for cellular energy and metabolism. Like with any
organ, the liver highly depends on the function of these cellular powerhouses. Hepatotoxic …

ABSTRACT A growing number of studies have suggested that traditional Chinese medicine
(TCM) plays an essential role in the development and occurrence of liver cancer. However …