The stereodivergent synthesis of natural product frameworks via a single transformation
using simple starting materials is a significant challenge. The prevalence of γ-butyrolactones …

Hinokinin is a lignan isolated from several plant species that has been recently investigated
in order to establish its biological activities. So far, its cytotoxicity, its anti-inflammatory and …

(R)-7 [(R)-AS-1] showed broad-spectrum antiseizure activity across in vivo mouse seizure
models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and …

Dysfunction of excitatory amino acid transporters (EAATs) has been implicated in the
pathogenesis of various neurological disorders, such as stroke, brain trauma, epilepsy, and …

Lignans are a large class of natural products that have been isolated from many plants. They
reveal diverse biological activities, especially antiviral and antitumor properties. From Piper …

We disclose a (terpy) NiBr2-catalyzed reaction protocol that regioselectively difunctionalizes
unactivated olefins with tethered alkyl halides and arylzinc reagents. The reaction shows an …

Excitatory amino acid transporters (EAATs) are essential CNS proteins that regulate
glutamate levels. Excess glutamate release and alteration in EAAT expression are …

Commiphora leptophloeos is a plant specie usually known for its medicinal purposes in
local communities in Northeast Brazil. In order to evaluate its therapeutic potential, we aimed …

Cubebin, isolated from the seeds of Piper cubeba, and its five different types of derivatives (a
total of 17), with varying functionalities, were tested for their in vitro anticancer activity …

Aim. The use of medicinal plants in the treatment of mental illnesses is a reality that
accompanies the history of civilizations, and the Piper genus exhibits many species with …