Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …

The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically
reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology …

Although injectable hydrogel microsphere has demonstrated tremendous promise in clinical
applications, local overactive inflammation in degenerative diseases could jeopardize …

The aetiology of intervertebral disc (IVD) degeneration remains poorly understood. Painful
IVD degeneration is associated with an acidic intradiscal pH but the response of NP cells to …

Background: Despite the therapeutic use of peptides is limited because of their metabolism
in vivo, there are no systematic reviews explaining degradation of peptides by peptidases …

Acid-sensing ion channels (ASICs) are proton-activated cation channels that are expressed
in a variety of neuronal and non-neuronal tissues. As proton-gated channels, they have …

Peptides have gained increased interest as therapeutics during recent years. More than 60
peptide drugs have reached the market for the benefit of patients and several hundreds of …

Introduction: Macrocyclic peptides are generally more resistant to proteolysis and often have
higher potency than linear peptides and so they are excellent leads in drug design. Their …

Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic
potential to treat pain and several neurodegenerative diseases. Inefficient assay-guided …

Abstract pH is one of the most strictly controlled parameters in mammalian physiology. An
extracellular pH of~ 7.4 is crucial for normal physiological processes, and perturbations to …