Long non-coding RNAs targeting tyrosine kinase overcome the drug resistance in pancreatic cancer
D Li, S Weng, K Zeng, H Xu, W Wang, J Shi, J Chen… - Gene, 2023 - Elsevier
Pancreatic cancer (PC) is one of the most malignant tumors with a dismal survival rate, this
is primarily due to inevitable chemoresistance. Dysfunctional tyrosine kinases (TKs) and …
is primarily due to inevitable chemoresistance. Dysfunctional tyrosine kinases (TKs) and …
[HTML][HTML] Role of STAT3 in pancreatic cancer
Z Hamel, S Sanchez, D Standing… - Exploration of Targeted …, 2024 - ncbi.nlm.nih.gov
Pancreatic cancer remains a serious and deadly disease, impacting people globally. There
remain prominent gaps in the current understanding of the disease, specifically regarding …
remain prominent gaps in the current understanding of the disease, specifically regarding …
An Ellagic Acid Coordinated Copper‐Based Nanoplatform for Efficiently Overcoming Cancer Chemoresistance by Cuproptosis and Synergistic Inhibition of Cancer …
S Lu, H Tian, B Li, L Li, H Jiang, Y Gao, L Zheng… - Small, 2024 - Wiley Online Library
Drug resistance is one of the leading causes of treatment failure in current cancer
chemotherapy. In addition to the classical drug efflux transporter‐mediated …
chemotherapy. In addition to the classical drug efflux transporter‐mediated …
Extracellular Matrix Collagen I Differentially Regulates the Metabolic Plasticity of Pancreatic Ductal Adenocarcinoma Parenchymal Cell and Cancer Stem Cell
D Tavares-Valente, S Cannone, MR Greco… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor
prognosis largely due to the intense fibrotic desmoplastic reaction, characterized by high …
prognosis largely due to the intense fibrotic desmoplastic reaction, characterized by high …
Silencing of keratin 15 impairs viability and mobility while facilitating the doxorubicin chemosensitivity by inactivating the β‑catenin pathway in liver cancer
J Wang, G Zhu - Oncology Letters, 2023 - spandidos-publications.com
Abstract Keratin 15 (KRT15) regulates the invasion as well as the stemness and is
associated with tumor size and metastasis of several gastrointestinal cancers apart from liver …
associated with tumor size and metastasis of several gastrointestinal cancers apart from liver …
IL20RB signaling enhances stemness and chemotherapy resistance in pancreatic cancer
X Li, G Huang, Z Xu, C Zhao, X Dong, B Cui… - Journal of Translational …, 2023 - Springer
Objective Pancreatic cancer is an aggressive malignancy with high mortality, and cancer cell
stemness and related drug resistance are considered important contributors to its poor …
stemness and related drug resistance are considered important contributors to its poor …
A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells
Background Pancreatic adenocarcinoma (PAAD) is one of the most fatal human cancers, but
effective therapies remain to be established. Cancer stem cells (CSCs) are highly resistant …
effective therapies remain to be established. Cancer stem cells (CSCs) are highly resistant …
CircMALAT1 promotes cancer stem‐like properties and chemoresistance via regulating Musashi‐2/c‐Myc axis in esophageal squamous cell carcinoma
Z Zhao, Y Deng, J Han, L Ma, Y Zhu, H Zhang… - MedComm, 2024 - Wiley Online Library
The primary challenge in treating esophageal squamous cell carcinoma (ESCC) is
resistance to chemotherapy. Cancer stem cell (CSC) is the root cause of tumor drug …
resistance to chemotherapy. Cancer stem cell (CSC) is the root cause of tumor drug …
Machine Learning Developed a MYC Expression Feature-Based Signature for Predicting Prognosis and Chemoresistance in Pancreatic Adenocarcinoma
B Dong, Y Zhang, H Gao, J Liu, J Li - Biochemical Genetics, 2024 - Springer
MYC has been identified to profoundly influence a wide range of pathologic processes in
cancers. However, the prognostic value of MYC-related genes in pancreatic …
cancers. However, the prognostic value of MYC-related genes in pancreatic …
Pathological Nodal and Vascular Involvement Significantly Impacts the Recurrence Risk in Different Time Frames in Patients with Resectable and Borderline …
H Takahashi, H Akita, H Wada, H Miyata… - Annals of …, 2023 - journals.lww.com
Objective: To investigate the long-term dynamics of recurrence risk and the significance of
prognostic variables using conditional recurrence-free survival (C-RFS) analysis in …
prognostic variables using conditional recurrence-free survival (C-RFS) analysis in …