The conformational states of the HIV-1 envelope glycoproteins
During HIV-1 entry into target cells, binding of the virus to host receptors, CD4 and
CCR5/CXCR4, triggers serial conformational changes in the envelope glycoprotein (Env) …
CCR5/CXCR4, triggers serial conformational changes in the envelope glycoprotein (Env) …
Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection
KO Saunders, RJ Edwards, K Tilahun… - Science translational …, 2022 - science.org
A successful HIV-1 vaccine will require induction of a polyclonal neutralizing antibody (nAb)
response, yet vaccine-mediated induction of such a response in primates remains a …
response, yet vaccine-mediated induction of such a response in primates remains a …
Vaccine-induced V1V2-specific antibodies control and or protect against infection with HIV, SIV and SHIV
S Zolla-Pazner, R Alvarez, XP Kong… - Current Opinion in HIV …, 2019 - journals.lww.com
Vaccine-induced V1V2-specific antibodies control and or prot... : Current Opinion in HIV and
AIDS Vaccine-induced V1V2-specific antibodies control and or protect against infection with …
AIDS Vaccine-induced V1V2-specific antibodies control and or protect against infection with …
Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein …
The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer mediates
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
The trimeric HIV-1 Envelope protein (Env) mediates viral-host cell fusion via a network of
conformational transitions, with allosteric elements in each protomer orchestrating host …
conformational transitions, with allosteric elements in each protomer orchestrating host …
Microsecond dynamics control the HIV-1 envelope conformation
AL Bennett, R Edwards, I Kosheleva, C Saunders… - Science …, 2024 - science.org
The HIV-1 Envelope (Env) glycoprotein facilitates host cell fusion through a complex series
of receptor-induced structural changes. Although remarkable progress has been made in …
of receptor-induced structural changes. Although remarkable progress has been made in …
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations
Abstract The HIV-1 envelope (Env) is the target for neutralizing antibodies and exists on the
surface of virions in open or closed conformations. Difficult-to-neutralize viruses (tier 2) …
surface of virions in open or closed conformations. Difficult-to-neutralize viruses (tier 2) …
Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env
The envelope glycoprotein (Env) is the sole target for neutralizing antibodies against HIV
and the most rapidly evolving, variable part of the virus. High-resolution structures of Env …
and the most rapidly evolving, variable part of the virus. High-resolution structures of Env …
Asymmetric structures and conformational plasticity of the uncleaved full-length human immunodeficiency virus envelope glycoprotein trimer
The functional human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer
[(gp120/gp41) 3] is produced by cleavage of a conformationally flexible gp160 precursor …
[(gp120/gp41) 3] is produced by cleavage of a conformationally flexible gp160 precursor …
Functional and highly cross-linkable HIV-1 envelope glycoproteins enriched in a pretriggered conformation
Binding to the receptor, CD4, drives the pretriggered,“closed”(state-1) conformation of the
human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer into more …
human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer into more …