A core challenge in biomedical and life science research is to decipher cell-to-cell
differences under pathological progression or external perturbation. Microfluidics-based …

Conspectus Single-molecule mechanochemical sensing (SMMS) is a novel biosensing
technique using mechanical force as a signal transduction mechanism. In the …

Exosomes are promising new biomarkers for colorectal cancer (CRC) diagnosis, due to their
rich biological fingerprints and high level of stability. However, the accurate detection of …

Flow cytometry is used routinely to measure single-cell gene expression by staining cells
with fluorescent antibodies and nucleic acids. Here, we present tension-activated cell …

A key challenge for achieving continuous biosensing with existing technologies is the poor
reusability of the biorecognition interface due to the difficulty in the dissociation of analytes …

Enhancers involved in the upregulation of multiple oncogenes play a fundamental role in
tumorigenesis and immortalization. Exploring the activity of enhancers in living cells has …

Probing nuclear protein expression while correlating cellular behavior is crucial for
deciphering underlying causes of cellular disorders, such as tumor metastasis. Despite …

Mechanical forces play a vital role in biological processes at molecular and cellular levels,
significantly impacting various diseases such as cancer, cardiovascular disease, and COVID …

Biological systems perceive and respond to mechanical forces, generating mechanical cues
to regulate life processes. Analyzing biomechanical forces has profound significance for …

In vitro, drug assessment holds tremendous potential to success in novel drug development
and precision medicine. Traditional techniques for drug assessment, however, face …