Antithrombotic therapy in patients with COVID-19?-Rationale and Evidence

C Godino, A Scotti, N Maugeri, N Mancini… - International journal of …, 2021 - Elsevier
In patients with severe or critical Coronavirus disease 2019 (COVID-19) manifestations, a
thromboinflammatory syndrome, with diffuse microvascular thrombosis, is increasingly …

Flavivirus infection—A review of immunopathogenesis, immunological response, and immunodiagnosis

HY Chong, CY Leow, ABA Majeed, CH Leow - Virus research, 2019 - Elsevier
Flaviviruses are group of single stranded RNA viruses that cause severe endemic infection
and epidemics on a global scale. It presents a significant health impact worldwide and the …

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin

CJ Mycroft-West, D Su, I Pagani… - Thrombosis and …, 2020 - thieme-connect.com
The dependence of development and homeostasis in animals on the interaction of hundreds
of extracellular regulatory proteins with the peri-and extracellular glycosaminoglycan …

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding

C Mycroft-West, D Su, S Elli, Y Li, S Guimond, G Miller… - BioRxiv, 2020 - biorxiv.org
Many pathogens take advantage of the dependence of the host on the interaction of
hundreds of extracellular proteins with the glycosaminoglycans heparan sulphate to …

Review of emerging Japanese encephalitis virus: new aspects and concepts about entry into the brain and inter-cellular spreading

L Filgueira, N Lannes - Pathogens, 2019 - mdpi.com
Japanese encephalitis virus (JEV) is an emerging flavivirus of the Asia-Pacific region. More
than two billion people live in endemic or epidemic areas and are at risk of infection …

The dual regulation of apoptosis by flavivirus

Y Pan, A Cheng, M Wang, Z Yin, R Jia - Frontiers in microbiology, 2021 - frontiersin.org
Apoptosis is a form of programmed cell death, which maintains cellular homeostasis by
eliminating pathogen-infected cells. It contains three signaling pathways: death receptor …

CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replication

C Zhao, H Liu, T Xiao, Z Wang, X Nie, X Li… - Nature …, 2020 - nature.com
Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic flavivirus that causes
encephalitis and reproductive disorders in mammalian species. However, the host factors …

The multifaceted roles of autophagy in flavivirus-host interactions

PY Ke - International journal of molecular sciences, 2018 - mdpi.com
Autophagy is an evolutionarily conserved cellular process in which intracellular components
are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and …

Zika virus protease induces caspase-independent pyroptotic cell death by directly cleaving gasdermin D

Y Yamaoka, S Matsunaga, SS Jeremiah, M Nishi… - Biochemical and …, 2021 - Elsevier
The association of Zika virus (ZIKV) infection with a congenital malformation in fetuses,
neurological, and other systemic complications in adults have brought significant global …

[HTML][HTML] Role of heparan sulfate in the Zika virus entry, replication, and cell death

H Gao, Y Lin, J He, S Zhou, M Liang, C Huang, X Li… - Virology, 2019 - Elsevier
Zika virus (ZIKV) is an emerging arbovirus and its infection associates with neurologic
diseases. Whether heparan sulfate (HS), an attachment factor for many viruses, plays a role …