Paving the way to single-molecule protein sequencing
Proteins are major building blocks of life. The protein content of a cell and an organism
provides key information for the understanding of biological processes and disease. Despite …
provides key information for the understanding of biological processes and disease. Despite …
Droplet-based microfluidics in biomedical applications
Droplet-based microfluidic systems have been employed to manipulate discrete fluid
volumes with immiscible phases. Creating the fluid droplets at microscale has led to a …
volumes with immiscible phases. Creating the fluid droplets at microscale has led to a …
Microfluidic single‐cell omics analysis
The commonly existing cellular heterogeneity plays a critical role in biological processes
such as embryonic development, cell differentiation, and disease progress. Single‐cell …
such as embryonic development, cell differentiation, and disease progress. Single‐cell …
Microtechnologies for single-cell and spatial multi-omics
Single-cell omics assays allow the identification of the type, subtype and functional state of a
single cell. To put such single-cell data in the context of tissues, spatially resolved omics can …
single cell. To put such single-cell data in the context of tissues, spatially resolved omics can …
[HTML][HTML] Circulating tumor cells in hepatocellular carcinoma: single-cell based analysis, preclinical models, and clinical applications
Q Zhang, Y Rong, K Yi, L Huang, M Chen, F Wang - Theranostics, 2020 - ncbi.nlm.nih.gov
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors and
metastatic lesions and provide significant information about tumor progression and …
metastatic lesions and provide significant information about tumor progression and …
Label‐free optofluidic nanobiosensor enables real‐time analysis of single‐cell cytokine secretion
Single‐cell analysis of cytokine secretion is essential to understand the heterogeneity of
cellular functionalities and develop novel therapies for multiple diseases. Unraveling the …
cellular functionalities and develop novel therapies for multiple diseases. Unraveling the …
Microfluidics towards single cell resolution protein analysis
Single cell analysis has aroused great interest with its remarkable ability to investigate cell-
to-cell heterogeneity in large populations. However, probing protein information at single …
to-cell heterogeneity in large populations. However, probing protein information at single …
A novel approach to design and fabricate an electrothermal microgripper for cell manipulation
Microgrippers are used in cell manipulation, micro-assembly, and material characterization.
However, rarely a systematic approach is presented for microgripper design. The current …
However, rarely a systematic approach is presented for microgripper design. The current …
Advancing single-cell proteomics and metabolomics with microfluidic technologies
Recent advances in single-cell analysis have unraveled substantial heterogeneity among
seemingly identical cells at genomic and transcriptomic levels. These discoveries have …
seemingly identical cells at genomic and transcriptomic levels. These discoveries have …
Mass spectrometry‐based strategies for single‐cell metabolomics
Single cell analysis has drawn increasing interest from the research community due to its
capability to interrogate cellular heterogeneity, allowing refined tissue classification and …
capability to interrogate cellular heterogeneity, allowing refined tissue classification and …