The role of leptin in health and disease

AM Ramos-Lobo, J Donato Jr - Temperature, 2017 - Taylor & Francis
Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts
important control on glucose homeostasis, thermogenesis, autonomic nervous system and …

BK channels in the central nervous system

C Contet, SP Goulding, DA Kuljis, AL Barth - International review of …, 2016 - Elsevier
Large conductance Ca 2+-and voltage-activated K+(BK) channels are widely distributed in
the postnatal central nervous system (CNS). BK channels play a pleiotropic role in …

[HTML][HTML] Leptin signaling in brain: a link between nutrition and cognition?

CD Morrison - Biochimica et biophysica acta (BBA)-molecular basis of …, 2009 - Elsevier
Leptin is a protein hormone that acts within the hypothalamus to suppress food intake and
decrease body adiposity, but it is increasingly clear that the hypothalamus is not the only site …

TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology

SE Dryer, J Reiser - American Journal of Physiology-Renal …, 2010 - journals.physiology.org
Loss or dysfunction of podocytes is a major cause of glomerular kidney disease. Several
genetic forms of glomerular disease are caused by mutations in genes that encode structural …

Leptin and its role in hippocampal synaptic plasticity

J Harvey, N Solovyova, A Irving - Progress in lipid research, 2006 - Elsevier
It is well documented that the hormone leptin plays a pivotal role in regulating food intake
and body weight via its hypothalamic actions. However, leptin receptors are expressed …

[HTML][HTML] Leptin regulation of neuronal excitability and cognitive function

J Harvey - Current opinion in pharmacology, 2007 - Elsevier
Leptin, a hormone produced by adipocytes, provides signals to specific regions of the
hypothalamus to control energy homeostasis. However, the past decade of research has not …

Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair

TJ Nelson, MK Sun, J Hongpaisan, DL Alkon - European journal of …, 2008 - Elsevier
Protein kinase C (PKC) is involved in synaptic remodeling, induction of protein synthesis,
and many other processes important in learning and memory. Activation of neuronal protein …

[HTML][HTML] Leptin promotes rapid dynamic changes in hippocampal dendritic morphology

D O'Malley, N MacDonald, S Mizielinska… - Molecular and Cellular …, 2007 - Elsevier
Recent studies have implicated the hormone leptin in synaptic plasticity associated with
neuronal development and learning and memory. Indeed, leptin facilitates hippocampal …

Leptin: a diverse regulator of neuronal function

J Harvey - Journal of neurochemistry, 2007 - Wiley Online Library
It is well documented that leptin is a circulating hormone that plays a key role in regulating
food intake and body weight via its actions on specific hypothalamic nuclei. However, leptin …

Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy

L Ge, NT Hoa, Z Wilson, G Arismendi-Morillo… - International …, 2014 - Elsevier
Abstract The Big Potassium (BK) ion channel is commonly known by a variety of names
(Maxi-K, KCNMA1, slo, stretch-activated potassium channel, KCa1. 1). Each name reflects a …