The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Cellular, Molecular and Clinical Aspects of Aortic Aneurysm—Vascular Physiology and Pathophysiology

D Domagała, K Data, H Szyller, M Farzaneh… - Cells, 2024 - mdpi.com
A disturbance of the structure of the aortic wall results in the formation of aortic aneurysm,
which is characterized by a significant bulge on the vessel surface that may have …

Genetic insights into therapeutic targets for aortic aneurysms: A Mendelian randomization study

Y Chen, X Xu, L Wang, K Li, Y Sun, L Xiao, J Dai… - …, 2022 - thelancet.com
Summary Background As aortic aneurysms (AAs) enlarge, they can become life-threatening
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …

Endothelial HDAC1-ZEB2-NuRD complex drives aortic aneurysm and dissection through regulation of protein S-sulfhydration

S Luo, C Kong, S Zhao, X Tang, Y Wang, X Zhou, R Li… - Circulation, 2023 - Am Heart Assoc
Background: Aortic aneurysm and aortic dissection (AAD) are life-threatening vascular
diseases, with endothelium being the primary target for AAD treatment. Protein S …

[HTML][HTML] Targeting regulated cell death in aortic aneurysm and dissection therapy

Y Chen, Y He, X Wei, DS Jiang - Pharmacological Research, 2022 - Elsevier
Regulated cell death (RCD) is a basic biological phenomenon associated with cell and
tissue homeostasis. Recent studies have enriched our understanding of RCD, and many …

Adventitial fibroblasts in aortic aneurysm: unraveling pathogenic contributions to vascular disease

CDA Mackay, AS Jadli, PWM Fedak, VB Patel - Diagnostics, 2022 - mdpi.com
Aortic aneurysm (AA) is a degenerative vascular disease that involves aortic dilatation, and,
if untreated, it can lead to rupture. Despite its significant impact on the healthcare system, its …

TGF‐β/Smads signaling pathway, Hippo‐YAP/TAZ signaling pathway, and VEGF: Their mechanisms and roles in vascular remodeling related diseases

H Liu, M Sun, N Wu, B Liu, Q Liu… - Immunity, Inflammation …, 2023 - Wiley Online Library
Vascular remodeling is a basic pathological process in various diseases characterized by
abnormal changes in the morphology, structure, and function of vascular cells, such as …

[HTML][HTML] Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications

Q Wang, G Yesitayi, B Liu, D Siti… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Aortic aneurysm and dissection (AAD) are a group of insidious and lethal cardiovascular
diseases that characterized by seriously threatening the life and health of people, but lack …

Insights on the pathogenesis of aneurysm through the study of hereditary aortopathies

TJ Creamer, EE Bramel, EG MacFarlane - Genes, 2021 - mdpi.com
Thoracic aortic aneurysms (TAA) are permanent and localized dilations of the aorta that
predispose patients to a life-threatening risk of aortic dissection or rupture. The identification …

Single-cell RNA-Seq analysis reveals macrophages are involved in the pathogenesis of human sporadic acute type A aortic dissection

B Zhang, K Zeng, RC Guan, HQ Jiang, YJ Qiang… - Biomolecules, 2023 - mdpi.com
Macrophages play an important role in the progression of sporadic acute type A aortic
dissection (ATAAD). The aim of this study was to characterize the cellular heterogeneity of …