Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

The prevalence of diabetes has been rising steadily in the past half-century, along with the
burden of its associated complications, including diabetic retinopathy (DR). DR is currently …

Background Glaucoma, the leading cause of irreversible blindness worldwide, is a type of
retinal disease characterized by the selective death of retinal ganglion cells (RGCs) …

Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …

Injury or insult to the adult nervous system often results in reactivation of signaling pathways
that are normally only active during development. The p75 neurotrophin receptor (p75 NTR) …

Sortilin is a type-1 receptor expressed in neurons of the central and peripheral nervous
systems. Initially considered a rather peculiar receptor resembling an intracellular sorting …

The optic nerve, like most pathways in the mature central nervous system, cannot
regenerate if injured, and within days, retinal ganglion cells (RGCs), the neurons that extend …

The p75 neurotrophin receptor (p75 NTR) functions at the molecular nexus of cell death,
survival, and differentiation. In addition to its contribution to neurodegenerative diseases and …

The p75 neurotrophin receptor (p75 NTR) regulates a wide range of cellular functions,
including programmed cell death, axonal growth and degeneration, cell proliferation …

Purpose.: This study aimed to determine retinal proteomic alterations in human glaucoma,
with particular focus on links to TNF-α/TNFR1 signaling. Methods.: Human retinal protein …