Bone turnover markers (BTMs) are used widely, in both research and clinical practice. In the
last 20 years, much experience has been gained in measurement and interpretation of these …

Osteoporosis is a global public health problem, with fractures contributing to significant
morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30 …

Bone is an exquisite example of the principle that form follows function. Bone provides
structural support for ambulation and ventilation; a reservoir for calcium, phosphate, amino …

Controlling the excessive fracture burden in patients with chronic kidney disease (CKD)
Stages G4–G5D remains an impressive challenge. The reasons are 2-fold. First, the …

Background The management of chronic kidney disease–mineral and bone disorder
requires the assessment of bone turnover, which most often is based on parathyroid …

Mineral and bone disease is omnipresent in patients with chronic kidney disease (CKD) and
leads to a diverse range of clinical manifestations, including bone pain and fractures. The …

High-resolution peripheral computed tomography (HR-pQCT) was developed to image bone
microarchitecture in vivo at peripheral skeletal sites. Since the introduction of HR-pQCT in …

Importance Dialysis-dependent patients experience high rates of morbidity from fractures,
yet little evidence is available on optimal treatment strategies. Chronic kidney disease …

Fractures are common in chronic kidney disease (CKD). The optimal methods by which to
assess fracture risk are unknown, in part, due to a lack of prospective studies. We …

Cortical bone structure is a crucial determinant of bone strength, yet for many years studies
of novel genes and cell signalling pathways regulating bone strength have focused on the …