Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …

Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …

Alzheimer's disease has a higher incidence in older women, with a spike in cognitive
decline that tracks with visceral adiposity, dysregulated energy homeostasis and bone loss …

Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering …

Exercise training has been widely recognized as a healthy lifestyle as well as an effective
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …

Myeloid-derived suppressor cells are a heterogeneous group of pathologically activated
immature cells that play a major role in the negative regulation of the immune response in …

Abstract Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17
(TH17) cell subset, has important roles in protecting the host against extracellular …

The inference of transcriptional networks that regulate transitions into physiological or
pathological cellular states remains a central challenge in systems biology. A mesenchymal …