Current and emerging pharmacological targets and treatments of urinary incontinence and related disorders

MC Michel, L Cardozo, CJ Chermansky, F Cruz… - Pharmacological …, 2023 - ASPET
Overactive bladder syndrome with and without urinary incontinence and related conditions,
signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract …

Potential future pharmacological treatment of bladder dysfunction

KE Andersson - Basic & clinical pharmacology & toxicology, 2016 - Wiley Online Library
In the last decades, a number of new antimuscarinic drugs have been introduced for
treatment of the overactive bladder (OAB), defined symptomatically (OAB syndrome) or …

[HTML][HTML] Cannabis-derived compounds cannabichromene and Δ9-tetrahydrocannabinol interact and exhibit cytotoxic activity against urothelial cell carcinoma …

O Anis, AC Vinayaka, N Shalev, D Namdar… - Molecules, 2021 - mdpi.com
Cannabis sativa contains more than 500 constituents, yet the anticancer properties of the
vast majority of cannabis compounds remains unknown. We aimed to identify cannabis …

[HTML][HTML] MicroRNAs may mediate the down-regulation of neurokinin-1 receptor in chronic bladder pain syndrome

VS Freire, FC Burkhard, TM Kessler, A Kuhn… - The American journal of …, 2010 - Elsevier
Bladder pain syndrome (BPS) is a clinical syndrome of pelvic pain and urinary urgency-
frequency in the absence of a specific cause. Investigating the expression levels of genes …

Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium

D Sellers, R Chess-Williams, MC Michel - … -Schmiedeberg's archives of …, 2018 - Springer
The epithelial inner layer of the lower urinary tract, ie, the urothelium, and other parts of the
mucosa are not just a passive barrier but play an active role in the sensing of stretching …

[HTML][HTML] A proteomic view of cellular and molecular effects of cannabis

M Abyadeh, V Gupta, JA Paulo, V Gupta, N Chitranshi… - Biomolecules, 2021 - mdpi.com
Cannabis (Cannabis sativa), popularly known as marijuana, is the most commonly used
psychoactive substance and is considered illicit in most countries worldwide. However, a …

[HTML][HTML] Prevalence and characteristics of cannabis-induced toxicoses in pets: Results from a survey of veterinarians in North America

RQ Amissah, NA Vogt, C Chen, K Urban, J Khokhar - Plos one, 2022 - journals.plos.org
Cannabis legalization in North America has coincided with an increase in reports of
cannabis-induced toxicosis in pets, but the magnitude of this problem, as well as outcomes …

[HTML][HTML] A survey for ketamine abuse and its relation to the lower urinary tract symptoms in Taiwan

CC Li, ST Wu, TL Cha, GH Sun, DS Yu, E Meng - Scientific reports, 2019 - nature.com
We aimed to explore the correlation between ketamine abuse and lower urinary tract
symptoms (LUTS) and epidemiology of ketamine cystitis. Questionnaire records of ketamine …

Effect of cannabidiol oil on post-ureteroscopy pain for urinary calculi: a randomized, double-blind, placebo-controlled trial

G Narang, J Moore, K Wymer, YH Chang… - The Journal of …, 2023 - auajournals.org
Purpose: Post-ureteroscopy stent placement carries significant morbidity which can interfere
with daily life. This discomfort unfortunately leads to high utilization of opioid pain …

Future direction in pharmacotherapy for non-neurogenic male lower urinary tract symptoms

R Soler, KE Andersson, MB Chancellor, CR Chapple… - European urology, 2013 - Elsevier
Background The pathophysiology of male lower urinary tract symptoms (LUTS) is highly
complex and multifactorial. The shift in perception that LUTS are not sex or organ specific …