The role of cellular reactive oxygen species in cancer chemotherapy
Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and
many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer …
many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer …
Mathematical modeling of tumor-immune cell interactions
GE Mahlbacher, KC Reihmer, HB Frieboes - Journal of Theoretical Biology, 2019 - Elsevier
The anti-tumor activity of the immune system is increasingly recognized as critical for the
mounting of a prolonged and effective response to cancer growth and invasion, and for …
mounting of a prolonged and effective response to cancer growth and invasion, and for …
Tumour‐associated microglia/macrophages predict poor prognosis in high‐grade gliomas and correlate with an aggressive tumour subtype
MD Sørensen, RH Dahlrot, HB Boldt… - Neuropathology and …, 2018 - Wiley Online Library
Aims Glioblastomas are highly aggressive and treatment resistant. Increasing evidence
suggests that tumour‐associated macrophages/microglia (TAMs) facilitate tumour …
suggests that tumour‐associated macrophages/microglia (TAMs) facilitate tumour …
[HTML][HTML] Redox control of cancer cell destruction
Redox regulation has been proposed to control various aspects of carcinogenesis, cancer
cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As …
cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As …
Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach
S Taylor, EP Spugnini, YG Assaraf, T Azzarito… - Drug Resistance …, 2015 - Elsevier
Despite the major progresses in biomedical research and the development of novel
therapeutics and treatment strategies, cancer is still among the dominant causes of death …
therapeutics and treatment strategies, cancer is still among the dominant causes of death …
Biodegradable Copper‐Based Nanoparticles Augmented Chemodynamic Therapy through Deep Penetration and Suppressing Antioxidant Activity in Tumors
R Zheng, Y Cheng, F Qi, Y Wu, X Han… - Advanced …, 2021 - Wiley Online Library
Chemodynamic therapy (CDT) efficacy has been limited by the poor penetration ability of
large nanoparticles (NPs) and the antioxidant activity of tumors, especially high heme …
large nanoparticles (NPs) and the antioxidant activity of tumors, especially high heme …
Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment
G Mahlbacher, LT Curtis, J Lowengrub… - … for immunotherapy of …, 2018 - Springer
Background Immuno-oncotherapy has emerged as a promising means to target cancer. In
particular, therapeutic manipulation of tumor-associated macrophages holds promise due to …
particular, therapeutic manipulation of tumor-associated macrophages holds promise due to …
Inhibition of growth and lung metastasis of breast cancer by tumor-homing triple-bioresponsive nanotherapeutics
Lung metastasis of breast cancer is a leading cause of cancer-related death in women.
Herein, we attempted to simultaneously inhibit the growth and lung metastasis of breast …
Herein, we attempted to simultaneously inhibit the growth and lung metastasis of breast …
The effects of frankincense essential oil on stress in rats
S Okano, Y Honda, T Kodama, M Kimura - Journal of Oleo Science, 2019 - jstage.jst.go.jp
Frankincense essential oil, obtained from Boswellia carteri, is a popular essential oil, which
is widely used in many parts of the world. While some of its properties are known, its effects …
is widely used in many parts of the world. While some of its properties are known, its effects …
Mathematical modeling in scheduling cancer treatment with combination of VEGF inhibitor and chemotherapy drugs
X Lai, A Friedman - Journal of Theoretical Biology, 2019 - Elsevier
The present paper considers a treatment of cancer with a combination of anti-VEGF
(bevacizumab) and a chemotherapy drug (docetaxel). Since anti-VEGF reduces the …
(bevacizumab) and a chemotherapy drug (docetaxel). Since anti-VEGF reduces the …