Role of calcium modulation in the pathophysiology and treatment of Alzheimer's disease

D Baracaldo-Santamaría, SS Avendaño-Lopez… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

Therapeutic potential of cannabis-related drugs

SPH Alexander - Progress in Neuro-Psychopharmacology and …, 2016 - Elsevier
In this review, I will consider the dual nature of Cannabis and cannabinoids. The duality
arises from the potential and actuality of cannabinoids in the laboratory and clinic and the …

Cannabis: a treasure trove or pandora's box?

K Solymosi, A Köfalvi - Mini reviews in medicinal chemistry, 2017 - ingentaconnect.com
Background & Objective: Cannabis is one of the earliest cultivated plants. Cannabis of
industrial utility and culinary value is generally termed as hemp. Conversely, cannabis that is …

Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex

T Manninen, A Saudargiene… - PLoS computational …, 2020 - journals.plos.org
Astrocytes have been shown to modulate synaptic transmission and plasticity in specific
cortical synapses, but our understanding of the underlying molecular and cellular …

Neuron–glia interactions and brain circuits

ML Linne, J Aćimović, A Saudargiene… - … modelling of the brain …, 2022 - Springer
Recent evidence suggests that glial cells take an active role in a number of brain functions
that were previously attributed solely to neurons. For example, astrocytes, one type of glial …

Synaptic plasticity in the auditory system: a review

E Friauf, AU Fischer, MF Fuhr - Cell and tissue research, 2015 - Springer
Synaptic transmission via chemical synapses is dynamic, ie, the strength of postsynaptic
responses may change considerably in response to repeated synaptic activation. Synaptic …

Challenges in reproducibility, replicability, and comparability of computational models and tools for neuronal and glial networks, cells, and subcellular structures

T Manninen, J Aćimović, R Havela… - Frontiers in …, 2018 - frontiersin.org
The possibility to replicate and reproduce published research results is one of the biggest
challenges in all areas of science. In computational neuroscience, there are thousands of …

Sativex in the Management of Multiple Sclerosis‐Related Spasticity: Role of the Corticospinal Modulation

M Russo, RS Calabrò, A Naro, E Sessa… - Neural …, 2015 - Wiley Online Library
Sativex is an emergent treatment option for spasticity in patients affected by multiple
sclerosis (MS). This oromucosal spray, acting as a partial agonist at cannabinoid receptors …

Short‐term plasticity regulates the excitation/inhibition ratio and the temporal window for spike integration in CA 1 pyramidal cells

AF Bartley, LE Dobrunz - European Journal of Neuroscience, 2015 - Wiley Online Library
Many neurodevelopmental and neuropsychiatric disorders involve an imbalance between
excitation and inhibition caused by synaptic alterations. The proper excitation/inhibition (E/I) …

[PDF][PDF] The economic impacts of marijuana legalization

DG Evans - Journal of Global Drug Policy and Practice, 2013 - dfaf.org
This is the first of a series of papers exploring the economic and social costs of legalizing
marijuana. The states of Washington and Colorado in the United Sates have legalized …