The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …

Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …

The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in
regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of …

Abstract PAKs, p21-activated kinases, play central roles and act as converging junctions for
discrete signals elicited on the cell surface and for a number of intracellular signaling …

Autophagy is a conserved and tightly regulated intracellular quality control pathway. ULK is
a key kinase in autophagy initiation, but whether ULK kinase activity also participates in the …

Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the
cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …

The mechanistic target of rapamycin, mTOR, controls cell metabolism in response to growth
signals and stress stimuli. The cellular functions of mTOR are mediated by two distinct …

Background The leading cause of cancer-related mortality worldwide is lung cancer, and its
clinical outcome and prognosis are still unsatisfactory. The understanding of potential …

Since the initial recognition of a mechanistic role of p21-activated kinase 1 (PAK1) in breast
cancer invasion, PAK1 has emerged as one of the widely overexpressed or hyperactivated …

Mechanistic target of rapamycin (mTOR) is a central signaling hub that integrates networks
of nutrient availability, cellular metabolism, and autophagy in eukaryotic cells. mTOR kinase …