PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson's disease
That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …
Cell biology and pathophysiology of α-synuclein
α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …
Patient-specific iPSC-derived astrocytes contribute to non-cell-autonomous neurodegeneration in Parkinson's disease
A di Domenico, G Carola, C Calatayud… - Stem cell reports, 2019 - cell.com
Parkinson's disease (PD) is associated with the degeneration of ventral midbrain
dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell …
dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell …
Reverse engineering Lewy bodies: how far have we come and how far can we go?
Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …
The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain
A Gasiorowska, M Wydrych, P Drapich… - Frontiers in aging …, 2021 - frontiersin.org
The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …
implications. Clinical and experimental studies on aging have uncovered numerous …
[HTML][HTML] Pathological roles of MAPK signaling pathways in human diseases
EK Kim, EJ Choi - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2010 - Elsevier
The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …
signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase (JNK), with each MAPK …
α-Synuclein in Parkinson's disease
L Stefanis - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
α-Synuclein is a presynaptic neuronal protein that is linked genetically and
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
N Exner, AK Lutz, C Haass, KF Winklhofer - The EMBO journal, 2012 - embopress.org
Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …
biochemical, and physiological features. They are characterized by high rates of metabolic …
[HTML][HTML] Parkinson's disease: mechanisms and models
W Dauer, S Przedborski - Neuron, 2003 - cell.com
Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …
Increased expression of α-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
The protein α-synuclein accumulates in the brain of patients with sporadic Parkinson's
disease (PD), and increased gene dosage causes a severe, dominantly inherited form of …
disease (PD), and increased gene dosage causes a severe, dominantly inherited form of …