Macrocyclic supramolecular complexes demonstrate the dynamic potential to solve global
biomedical challenges, a promising cancer treatment modality. The macrocyclic system is an …

Cancer is a serious disease that has been around for a long time but currently has no
sustainable solution. Several medications currently available offer an opportunity for the …

The Biginelli reaction found a prominent place among multicomponent reactions owing to
the widespread pharmacological importance of the products dihydropyrimidinones …

The acetophenone-based 3, 4-dihydropyrimidine-2 (1H)-thione was synthesized by the
reaction of 4-methylpent-3-en-2-one (1), 4-acetyl aniline (2) and potassium thiocyanate. The …

Graphene oxide (GO) nanocomposites have attracted much attention in biomedical and
catalytic fields due to their outstanding water dispersibility, cell permeability, high mobility of …

In present work, the application of a novel set of 1, 8-Diazabicyclo [5.4. 0] undec-7-ene
(DBU) and methylimidazole (MIm) coupled ionic liquids (ILs) in the Biginelli reaction has …

Biginelli-type heterocyclic compounds are particularly important due to their several
chemical reactivities and various range of pharmacological activity. Therefore Biginelli …

Background: In synthetic and medicinal chemistry, multi-component reactions (MCRs) are
considered an essential tool in synthesizing bioactive heterocyclic scaffolds. These …

Novel dihydropyrimidines incorporating an adamantane motif have been synthesized using
a three-component Biginelli reaction of adamantane-containing β-keto amide N-1 …

In this study, a novel pyridone-based phthalimide fleximer, that is, ethyl 5-cyano-6-(3-(1, 3-
dioxoisoindolin-2-yl) propoxy)-4-(3-methoxyphenyl)-2-methylnicotinate, was synthesized …