Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects
approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune …

Emerging evidence points toward an intricate relationship between the pandemic of
coronavirus disease 2019 (COVID-19) and diabetes. While preexisting diabetes is …

Dipeptidyl peptidase-4 (DPP4) is a serine protease that rapidly inactivates the incretin
peptides, glucagon-like peptide-1, and glucose-dependent insulinotropic polypeptide to …

Background and aims Molecular evidence of cellular heterogeneity in the human exocrine
pancreas has not been yet established, due to the local concentration and cascade of …

Abstract Objective Pancreatic islets of Langerhans secrete hormones to regulate systemic
glucose levels. Emerging evidence suggests that islet cells are functionally heterogeneous …

Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone that potentiates glucose-
stimulated insulin secretion. GLP-1 is classically produced by gut L cells; however, under …

The physiological functions of many vital tissues and organs continue to mature after birth,
but the genetic mechanisms governing this postnatal maturation remain an unsolved …

Recent studies demonstrate that α cells contribute to glucose-stimulated insulin secretion
(GSIS). Glucagon-like peptide-1 receptor (GLP-1R) agonists potently potentiate GSIS …

The complement system is an important component of transplant rejection. Sertoli cells, an
immune regulatory testicular cell, survive long-term when transplanted across …

Pancreatic islets are vital endocrine regulators of systemic metabolism, and recent
investigations have increasingly focused on understanding human islet biology. Studies of …