▪ Abstract We review the current status of research in dorsal-ventral (DV) patterning in
vertebrates. Emphasis is placed on recent work on Xenopus, which provides a paradigm for …

The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of
development. This period is characterized by the formation of the anterior-posterior and …

Signaling by the transforming growth factor β (TGF-β) family is necessary for proper neural
development and function throughout life. Sequential waves of activation, inhibition, and …

TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …

Scientists and clinicians who study genetic alterations and disease have traditionally
described phenotypes in natural language. The considerable variation in these free-text …

All processes that occur before the activation of the zygotic genome at the midblastula
transition are driven by maternal products, which are produced during oogenesis and stored …

Transplanted Spemann's organizer induces dorsal embryonic cell fates such as the nervous
system and somites, but in normal development, elimination of individual organizer signals …

Vertebrate development begins with precise molecular, cellular, and morphogenetic controls
to establish the basic body plan of the embryo. In zebrafish, these tightly regulated …

In order to generate the tissues and organs of a multicellular organism, different cell types
have to be generated during embryonic development. The first step in this process of cellular …

The establishment of dorsoventral (DV) patterning in vertebrate embryos depends on the
morphogenic activity of a group of Tgfβ superfamily members, the bone morphogenetic …