Antiplatelet medications comprise the cornerstone of treatment for diseases that involve
arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral …

Platelets are small anucleate blood cells that play vital roles in haemostasis and thrombosis,
besides other physiological and pathophysiological processes. These roles are tightly …

The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous
thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on …

Although platelets and the coagulation factors are components of the blood system, they
become part of and contribute to the tumor microenvironment (TME) not only within a solid …

The anucleate human platelets contain a broad pattern of mRNAs and other RNA
transcripts. The high quantitative similarity of mRNAs in megakaryocytes and platelets from …

Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat
inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs …

Histidine-rich glycoprotein (HRG) is a multifunctional plasma protein and maintains the
homeostasis of blood cells and vascular endothelial cells. In the current study, we …

Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Millions of
people worldwide display mildly elevated levels of plasma lipids and cholesterol linked to …

The importance of platelets for cardiovascular disease was established as early as the 19th
century. Their therapeutic inhibition stands alongside the biggest achievements in medicine …

Abstract F11 receptor (F11R)/Junctional Adhesion Molecule–A (JAM-A) is a transmembrane
protein which belongs to the immunoglobulin superfamily of cell adhesion molecules …