Tumour formation involves random mutagenic events and positive evolutionary selection
acting on a subset of such events, referred to as driver mutations. A decade of careful …

The same genetic variant found in different individuals can cause a range of diverse
phenotypes, from no discernible clinical phenotype to severe disease, even among related …

Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …

Abstract Design of de novo synthetic regulatory DNA is a promising avenue to control gene
expression in biotechnology and medicine. Using mutagenesis typically requires screening …

The recent increase in genomic data is revealing an unexpected perspective of gene loss as
a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This …

Recent achievements in plant microRNA (miRNA), a large class of small and non-coding
RNAs, are very exciting. A wide array of techniques involving forward genetic, molecular …

Long mammalian introns make it challenging for the RNA processing machinery to identify
exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection …

Throughout evolution, new transcription factors (TFs) emerge by gene duplication,
promoting growth and rewiring of transcriptional networks. How TF duplicates diverge was …

The most recent genome-wide association study (GWAS) of cutaneous melanoma identified
54 risk-associated loci, but functional variants and their target genes for most have not been …

Multiple cell-signalling pathways converge on chromatin to induce gene expression
programmes. The inducible transcriptional programmes that are established as a result of …