Myelodysplastic syndrome (MDS) typically presents in older adults with the acquisition of
age-related somatic mutations, whereas MDS presenting in children and younger adults is …

The discovery of the GATA binding protein (GATA factor) transcription factor family
revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our …

Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to
patients with sickle cell disease and some forms of β-thalassemia. To identify potentially …

Long thought to be too big and too ubiquitous to fail, we now know that human cells can fail
to make sufficient amounts of ribosomes, causing a number of diseases collectively known …

Endometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-
methylcytosine (m 5 C) modification of mRNA is a crucial epigenetic modification associated …

Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with
biological membranes. The very same properties of heme that nature exploits to support life …

Ribosome dysfunction underlies the pathogenesis of many cancers and heritable
ribosomopathies. Here, we investigate how mutations in either ribosomal protein large …

Diamond-Blackfan anemia (DBA) is a rare congenital bone marrow failure disorder
characterized by erythroid hypoplasia. It primarily affects infants and is often caused by …

Diamond-Blackfan anemia (DBA) was the first ribosomopathy described and is a
constitutional inherited bone marrow failure syndrome. Erythroblastopenia is the major …

Diamond-Blackfan anemia (DBA) is a congenital disorder characterized by the failure of
erythroid progenitor differentiation, severely curtailing red blood cell production. Because …