Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in
various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is …

Despite the enormous progress in the treatment of atrial fibrillation, mainly with the use of
invasive techniques, many questions remain unanswered regarding the pathomechanism of …

Fatty acid oxidation (FAO) is a key bioenergetic pathway often dysregulated in diseases. The
current knowledge on FAO regulators in mammalian cells is limited and sometimes …

Chronic heart failure is a common complication in patients with type 2 diabetes mellitus
(T2DM). T2DM is associated with disturbed metabolism of fat, which can result in excessive …

ABSTRACT M2-like tumor-associated macrophages promote tumor progression by
establishing an immunosuppressive tumor microenvironment. The phenotype and activity of …

Background Previous studies have shown that Trimetazidine (TMZ) improves vascular
endothelial function and reduces the inflammatory process progression. However, limited …

Background: Cardiovascular diseases (CVDs) are one of the main factors responsible for
human morbidity and mortality. Since mitochondria play a critical role in the regulation of …

Background Heart failure (HF) is one of the leading causes of death worldwide and is
associated with cardiac metabolic perturbations. Human Type 2 Berardinelli‐Seip …

Amyotrophic Lateral Sclerosis (ALS) is considered the prototype of motor neuron disease,
characterized by motor neuron loss and muscle waste. A well-established pathogenic …

Цель. Анализ эффективности лекарственных препаратов с преимущественно
антигипоксическим действием в лечении митохондриальных дисфункций (МД) …