Abstract γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid
organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …

T cells of the γδ lineage are unconventional T cells with functions not restricted to MHC-
mediated antigen presentation. Because of their broad antigen specificity and NK-like …

The functional role of CD8+ lymphocytes in tuberculosis remains poorly understood. We
depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all …

Summary Vγ9Vδ2 T cells respond in a TCR-dependent fashion to both microbial and host-
derived pyrophosphate compounds (phosphoantigens, or P-Ag). Butyrophilin-3A1 …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Vγ9Vδ2 T cells are the largest population of γδ T cells in adults and can play important roles
in providing effective immunity against cancer and infection. Many studies have suggested …

Summary γδ T cells comprise the third cell lineage of lymphocytes that use, like αβ T cells
and B cells, V (D) J gene rearrangement with the potential to generate a highly diverse T cell …

Pathogenesis hallmarks for tuberculosis (TB) are the Mycobacterium tuberculosis (Mtb)
escape from phagolysosomal destruction and limited drug delivery into infected cells …