In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

Microglia are critical nervous system‐specific immune cells serving as tissue‐resident
macrophages influencing brain development, maintenance of the neural environment …

One of the most striking hallmarks shared by various neurodegenerative diseases, including
Parkinson's disease, Alzheimer's disease (AD), and amyotrophic lateral sclerosis, is …

Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and
during central nervous system (CNS) inflammation. It was initially suggested that these …

In recent years, many paradigms concerning central nervous system (CNS) immunology
have been challenged and shifted, including the discovery of CNS-draining lymphatic …

The concept of multiple macrophage activation states is not new. However, extending this
idea to resident tissue macrophages, like microglia, has gained increased interest in recent …

Microglia are resident macrophages of the central nervous system that contribute to
homeostasis and neuroinflammation. Although known to play an important role in brain …

Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques,
neurofibrillary tangles, and neuronal loss, accompanied by neuroinflammation …