Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

CW Shields Iv, CD Reyes, GP López - Lab on a Chip, 2015 - pubs.rsc.org
Accurate and high throughput cell sorting is a critical enabling technology in molecular and
cellular biology, biotechnology, and medicine. While conventional methods can provide high …

Fundamentals and application of magnetic particles in cell isolation and enrichment: a review

BD Plouffe, SK Murthy, LH Lewis - Reports on Progress in …, 2014 - iopscience.iop.org
Magnetic sorting using magnetic beads has become a routine methodology for the
separation of key cell populations from biological suspensions. Due to the inherent ability of …

Extracellular matrix in synthetic hydrogel‐based prostate cancer organoids regulate therapeutic response to EZH2 and DRD2 inhibitors

MJ Mosquera, S Kim, R Bareja, Z Fang… - Advanced …, 2022 - Wiley Online Library
Following treatment with androgen receptor (AR) pathway inhibitors,≈ 20% of prostate
cancer patients progress by shedding their AR‐dependence. These tumors undergo …

Chitosan 3D cell culture system promotes naïve-like features of human induced pluripotent stem cells: A novel tool to sustain pluripotency and facilitate differentiation

PH Chang, HM Chao, E Chern, S Hsu - Biomaterials, 2021 - Elsevier
A simplified and cost-effective culture system for maintaining the pluripotency of human
induced pluripotent stem cells (hiPSCs) is crucial for stem cell applications. Although …

Human-on-chip for therapy development and fundamental science

C Luni, E Serena, N Elvassore - Current opinion in biotechnology, 2014 - Elsevier
Highlights•Organ-on-chip technology is rapidly evolving towards fundamental applications.•
Regulatory agencies preview organ-on-chips as tools for safer and affordable …

Induced pluripotent stem cells for regenerative medicine

KK Hirschi, S Li, K Roy - Annual review of biomedical …, 2014 - annualreviews.org
With the discovery of induced pluripotent stem (iPS) cells, it is now possible to convert
differentiated somatic cells into multipotent stem cells that have the capacity to generate all …

High-efficiency cellular reprogramming with microfluidics

C Luni, S Giulitti, E Serena, L Ferrari, A Zambon… - Nature …, 2016 - nature.com
We report that the efficiency of reprogramming human somatic cells to induced pluripotent
stem cells (hiPSCs) can be dramatically improved in a microfluidic environment. Microliter …

Engineering and evaluating drug delivery particles in microfluidic devices

M Björnmalm, Y Yan, F Caruso - Journal of Controlled Release, 2014 - Elsevier
The development of new and improved particle-based drug delivery is underpinned by an
enhanced ability to engineer particles with high fidelity and integrity, as well as increased …

Multiscale engineering of immune cells and lymphoid organs

S Kim, SB Shah, PL Graney, A Singh - Nature Reviews Materials, 2019 - nature.com
Immunoengineering applies quantitative and materials-based approaches for the
investigation of the immune system and for the development of therapeutic solutions for …

Engineered human contractile myofiber sheets as a platform for studies of skeletal muscle physiology

H Takahashi, T Shimizu, T Okano - Scientific Reports, 2018 - nature.com
Skeletal muscle physiology and the mechanisms of muscle diseases can be effectively
studied by an in-vitro tissue model produced by muscle tissue engineering. Engineered …