Intracerebral haemorrhage: mechanisms of injury and therapeutic targets
RF Keep, Y Hua, G Xi - The Lancet Neurology, 2012 - thelancet.com
Intracerebral haemorrhage accounts for about 10–15% of all strokes and is associated with
high mortality and morbidity. No successful phase 3 clinical trials for this disorder have been …
high mortality and morbidity. No successful phase 3 clinical trials for this disorder have been …
The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes
TJ Woodruff, P Sutton - Environmental health perspectives, 2014 - ehp.niehs.nih.gov
Background: Synthesizing what is known about the environmental drivers of health is
instrumental to taking prevention-oriented action. Methods of research synthesis commonly …
instrumental to taking prevention-oriented action. Methods of research synthesis commonly …
Risk of bias in reports of in vivo research: a focus for improvement
MR Macleod, A Lawson McLean, A Kyriakopoulou… - PLoS …, 2015 - journals.plos.org
The reliability of experimental findings depends on the rigour of experimental design. Here
we show limited reporting of measures to reduce the risk of bias in a random sample of life …
we show limited reporting of measures to reduce the risk of bias in a random sample of life …
Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically
The use of systematic review and meta-analysis of preclinical studies has become more
common, including those of studies describing the modeling of cerebrovascular diseases …
common, including those of studies describing the modeling of cerebrovascular diseases …
The need for randomization in animal trials: an overview of systematic reviews
Background and Objectives Randomization, allocation concealment, and blind outcome
assessment have been shown to reduce bias in human studies. Authors from the …
assessment have been shown to reduce bias in human studies. Authors from the …
[HTML][HTML] Systematic reviews of animal models: methodology versus epistemology
R Greek, A Menache - International journal of medical sciences, 2013 - ncbi.nlm.nih.gov
Systematic reviews are currently favored methods of evaluating research in order to reach
conclusions regarding medical practice. The need for such reviews is necessitated by the …
conclusions regarding medical practice. The need for such reviews is necessitated by the …
[HTML][HTML] Advanced methods and implementations for the meta-analyses of animal models: Current practices and future recommendations
Meta-analytic techniques have been widely used to synthesize data from animal models of
human diseases and conditions, but these analyses often face two statistical challenges due …
human diseases and conditions, but these analyses often face two statistical challenges due …
Refinement of experimental design and conduct in laboratory animal research
The scientific literature of laboratory animal research is replete with papers reporting poor
reproducibility of results as well as failure to translate results to clinical trials in humans. This …
reproducibility of results as well as failure to translate results to clinical trials in humans. This …
The role of inflammation in neurological disorders
Traditionally neurological diseases have been classified, on the basis of their pathogenesis,
into vascular, degenerative, inflammatory and traumatic diseases. Examples of the main …
into vascular, degenerative, inflammatory and traumatic diseases. Examples of the main …
Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?
Background: Malignant glioma is an aggressive tumour commonly associated with a dismal
outcome despite optimal surgical and radio-chemotherapy. Since 2005 temozolomide has …
outcome despite optimal surgical and radio-chemotherapy. Since 2005 temozolomide has …