Life-style changes, environmental pollution, and genetic factors have resulted in a large
number of diseases to human beings. Though plant extracts have been widely used to …

Provided are compounds that are inhibitors of both rho kinase and of a monoamine
transporter (MAT) act to improve the disease state or condition. Further provided are …

Provided herein are arylcyclopropyl amino-isoquinoline amide compounds. In particular, the
disclosure provides compounds that affect the function of kinases in a cell and that are …

The present disclosure provides an ophthalmic composition comprising 4-(3-amino-1-
(isoquinolin-6-ylamino)-1-oxopropan-2-yl) benzyl 2, 4-dimethylbenzoate or its …

Related US Application Data Continuation of application No. 15/627,238, filed on Jun. 19,
2017, now Pat. No. 9,993,470, which is a continuation of application No. 15/142,461, filed on …

C07C 237/20(2006. 01) CO7D 401/12(2006. 01) CO7D 409/12(2006. 01) C07C
237/42(2006. 01) CO7D 333/40 (2006. 01) CO7D 217/04(2006. 01) C07D 217/02(2006. 01) …

Amino isoquinoline compounds are provided that influ-ence, inhibit or reduce the action of a
kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6 …

Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted
benzamide compounds. In par ticular, the invention provides compounds that affect the …

7470, 787 B2 12/2008 deLong et al. 2 ()|| 6/() 272589) A| 9/2016 deLong et al. 7671.205 B2
3/2010 deLong et al. 2 () 16/() 28 () 656 A1 92016 deLong et al. 8034943 B2 10/2011 …

Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted
benzamide compounds. In particular, the invention provides compounds that affect the …