Intracellular signalling pathways have provided excellent resource for drug development
particularly in the development of cancer therapeutics. A wide variety of malignancies …

Gastrointestinal (GI) side-effects of chemotherapy are a debilitating and often overlooked
clinical hurdle in cancer management. Chemotherapy-induced constipation (CIC) and …

Background First-line pembrolizumab monotherapy improves overall and progression-free
survival in patients with untreated metastatic non-small-cell lung cancer with a programmed …

Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) plays a critical role in the base
excision repair (BER) pathway, which is responsible for the excision of apurinic sites (AP …

Cisplatin is a highly effective antitumor agent whose clinical application is limited by the
inherent nephrotoxicity. The current measures of nephroprotection used in patients receiving …

Background Previous studies have demonstrated the efficacy and safety of bevacizumab in
the treatment of non-small-cell lung cancer (NSCLC). Methods Summary data from …

Abstract Background Tumor-associated macrophages (TAMs) play a critical role in
modulating the tumor microenvironment and promote tumor metastases. Our studies have …

PURPOSE Larotrectinib is a highly selective and CNS-active tropomyosin receptor kinase
(TRK) inhibitor that has demonstrated efficacy across TRK fusion–positive cancers …

To complement the existing treatment guidelines for all tumour types, ESMO organises
consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO …

Introduction 3. NF-kappaB activation pathways 3.1. Protein components in the NF-kappaB
family 3.2. The pathways leading to NF-kappaB activation 4. NF-kappaB's cellular functions …