Abstract N 7-methylguanosine (m7G), one of the most prevalent RNA modifications, has
recently attracted significant attention. The m7G modification actively participates in …

DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …

Background Pancreatic cancer is the most lethal cancer with a dismal prognosis mainly due
to diagnosis at advanced stage and ineffective treatments. CA19-9 levels and computed …

Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …

Pancreatic cancer (PC) is one of the most aggressive and devastating types of cancer owing
to its poor prognosis and deadly characteristics. It is well established that aberrations in the …

Obesity is a prominent health issue worldwide and directly impacts pancreatic health, with
obese individuals exhibiting a significant risk for increasing pancreatic ductal …

There is an urgent need to identify new cellular targets to expand the repertoire, potency and
safety of cancer therapeutics. Neonatal Fc Receptor (FcRn)-driven cellular recycling plays a …

It has recently been proven that epigenetic dysregulation is importantly involved in cell
transformation and therefore induces cancerous diseases. The development of molecules …

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-
coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through …

The immune system plays a vital role in maintaining the delicate balance between immune
recognition and tumor development. Regardless, it is not uncommon that cancerous cells …