The multifunctional role of herbal products in the management of diabetes and obesity: a comprehensive review

MM Rahman, MR Islam, S Shohag, ME Hossain… - Molecules, 2022 - mdpi.com
Obesity and diabetes are the most demanding health problems today, and their prevalence,
as well as comorbidities, is on the rise all over the world. As time goes on, both are …

Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver

GH Goossens, JWE Jocken, EE Blaak - Nature Reviews Endocrinology, 2021 - nature.com
Obesity is associated with many adverse health effects, such as an increased
cardiometabolic risk. Despite higher adiposity for a given BMI, premenopausal women are at …

Richness of human gut microbiome correlates with metabolic markers

E Le Chatelier, T Nielsen, J Qin, E Prifti, F Hildebrand… - Nature, 2013 - nature.com
We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we
report the human gut microbial composition in a population sample of 123 non-obese and …

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

M Pigeyre, FT Yazdi, Y Kaur, D Meyre - Clinical science, 2016 - portlandpress.com
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Relationships between rodent white adipose fat pads and human white adipose fat depots

DE Chusyd, D Wang, DM Huffman, TR Nagy - Frontiers in nutrition, 2016 - frontiersin.org
The objective of this review was to compare and contrast the physiological and metabolic
profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat …

Determinants of body fat distribution in humans may provide insight about obesity-related health risks

AP Frank, R de Souza Santos, BF Palmer… - Journal of lipid …, 2019 - ASBMB
Obesity increases the risks of developing cardiovascular and metabolic diseases and
degrades quality of life, ultimately increasing the risk of death. However, not all forms of …

The bigger picture of FTO—the first GWAS-identified obesity gene

RJF Loos, GSH Yeo - Nature Reviews Endocrinology, 2014 - nature.com
Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …

Sex differences in human adipose tissues–the biology of pear shape

K Karastergiou, SR Smith, AS Greenberg… - Biology of sex …, 2012 - Springer
Women have more body fat than men, but in contrast to the deleterious metabolic
consequences of the central obesity typical of men, the pear-shaped body fat distribution of …

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

EK Speliotes, CJ Willer, SI Berndt, KL Monda… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Quality control and conduct of genome-wide association meta-analyses

TW Winkler, FR Day, DC Croteau-Chonka, AR Wood… - Nature protocols, 2014 - nature.com
Rigorous organization and quality control (QC) are necessary to facilitate successful
genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple …