The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

Intracellular pH (pHi) regulation in the brain is important in both physiological and
physiopathological conditions because changes in pHi generally result in altered neuronal …

Mammalian genomes contain 10 SLC4 genes that, between them, encode three Cl–HCO3
exchangers, five Na+-coupled HCO3 transporters (NCBTs), one reported borate transporter …

The solute carrier SLC4 family consists of 10 members, nine of which are HCO 3-
transporters, including three Na+-independent Cl−/HCO 3-exchangers AE1, AE2, and AE3 …

The SLC4A10 gene product, commonly known as NCBE, is highly expressed in rodent brain
and has been characterized by others as a Na+-driven Cl-HCO 3 exchanger. However …

Background Differentiating among HCO 3−, CO 3=, and H+ movements across membranes
has long seemed impossible. We now seek to discriminate unambiguously among three …

The choroid plexus lining the four ventricles in the brain is where the majority of
cerebrospinal fluid (CSF) is produced. The secretory function of the choroid plexus is …

Transepithelial fluid secretion across the renal (Malpighian) tubule epithelium of the
mosquito (Aedes aegypti) is energized by the vacuolar-type (V-type) H+-ATPase and not the …

The kidney maintains systemic acid-base balance by reclaiming from the renal tubule lumen
virtually all HCO 3− filtered in glomeruli and by secreting additional H+ to titrate luminal …

The Na+-driven Cl-HCO3 exchanger (NDCBE or SLC4A8) is a member of the solute carrier
4 (SLC4) family of HCO3− transporters, which includes products of 10 genes with similar …