Bioactive lipids, inflammation and chronic diseases

A Leuti, D Fazio, M Fava, A Piccoli, S Oddi… - Advanced Drug Delivery …, 2020 - Elsevier
Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Changes in plasma free fatty acids associated with type-2 diabetes

A IS Sobczak, C A. Blindauer, A J. Stewart - Nutrients, 2019 - mdpi.com
Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid
(FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms …

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

HB Beyene, G Olshansky, AA T. Smith, C Giles… - PLoS …, 2020 - journals.plos.org
Obesity and related metabolic diseases show clear sex-related differences. The growing
burden of these diseases calls for better understanding of the age-and sex-related metabolic …

Plasma metabolite profiles related to plant-based diets and the risk of type 2 diabetes

F Wang, MY Baden, M Guasch-Ferré, C Wittenbecher… - Diabetologia, 2022 - Springer
Aims/hypothesis Plant-based diets, especially when rich in healthy plant foods, have been
associated with a lower risk of type 2 diabetes. However, whether plasma metabolite profiles …

An updated review of pro-and anti-inflammatory properties of plasma lysophosphatidylcholines in the vascular system

E Knuplez, G Marsche - International Journal of Molecular Sciences, 2020 - mdpi.com
Lysophosphatidylcholines are a group of bioactive lipids heavily investigated in the context
of inflammation and atherosclerosis development. While present in plasma during …

Ceramides as mediators of oxidative stress and inflammation in cardiometabolic disease

M Gaggini, R Ndreu, E Michelucci… - International Journal of …, 2022 - mdpi.com
Ceramides, composed of a sphingosine and a fatty acid, are bioactive lipid molecules
involved in many key cellular pathways (eg, apoptosis, oxidative stress and inflammation) …

Deep lipidomics in human plasma: cardiometabolic disease risk and effect of dietary fat modulation

F Eichelmann, L Sellem, C Wittenbecher, S Jäger… - Circulation, 2022 - Am Heart Assoc
Background: In blood and tissues, dietary and endogenously generated fatty acids (FAs)
occur in free form or as part of complex lipid molecules that collectively represent the …

[HTML][HTML] Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease

AJ McGlinchey, O Govaere, D Geng, V Ratziu… - Jhep Reports, 2022 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) is a progressive liver disease
with potentially severe complications including cirrhosis and hepatocellular carcinoma …

Dapagliflozin reduces apoptosis of diabetic retina and human retinal microvascular endothelial cells through ERK1/2/cPLA2/AA/ROS pathway independent of …

Y Hu, Q Xu, H Li, Z Meng, M Hao, X Ma, W Lin… - Frontiers in …, 2022 - frontiersin.org
Introduction: It is known that the metabolic disorder caused by high glucose is one of
pathogenesis in diabetic retinopathy (DR), the leading cause of blindness, due to the main …

Nutrients in the Prevention of Alzheimer's Disease

AL Cremonini, I Caffa, M Cea… - Oxidative medicine …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a disease caused by the complex interaction of multiple
mechanisms, some of which are still not fully understood. To date, pharmacological …