Disuse and aging are known risk factors associated with low bone mass and quality
deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence …

The use of deuterium oxide (D2O) has greatly expanded the scope of what is possible for
the measurement of protein synthesis. The greatest asset of D2O labeling is that it facilitates …

A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty
in older persons, but the molecular mechanisms of such decline are not understood. Here …

During aging, muscle gradually undergoes sarcopenia, the loss of function associated with
loss of mass, strength, endurance, and oxidative capacity. However, the 3D structural …

The causes of the decline in skeletal muscle mass and function with age, known as
sarcopenia, are poorly understood. Nutrition (calorie restriction) interventions impact many …

Background Muscle atrophy is a common pathology associated with disuse, such as
prolonged bed rest or spaceflight, and is associated with detrimental health outcomes. There …

Age-related deterioration in turnover of collagen proteins accelerates extracellular matrix
fibrosis and hinders adaptation to external stimuli. This project sought to understand factors …

Background Translational capacity (ie ribosomal mass) is a key determinant of protein
synthesis and has been associated with skeletal muscle hypertrophy. The role of …

Ubiquitination is an important post-translational modification (PTM) for protein substrates,
whereby ubiquitin is added to proteins through the coordinated activity of activating (E1) …

Background Skeletal muscle mass and strength diminish during periods of disuse but
recover upon return to weight bearing in healthy adults but are incomplete in old muscle …