Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis,
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …

Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Lysosome dysfunction arises early and propels Alzheimer's disease (AD). Herein, we show
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …

The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely
correlated with the cellular availability of glucose. When glucose levels are low, the …

Macroautophagy is a dynamic process involving the rearrangement of subcellular
membranes to sequester cytoplasm and organelles for delivery to the lysosome or vacuole …

Masaki1, and Yutaka Tashiro1 department of Physiology and Liver Research Center (Cell
Biology), Kansai Medical University, Moriguchi, Osaka 570-0074, and^ Department of Cell …

Autophagy is a highly conserved process in eukaryotes in which the cytoplasm, including
excess or aberrant organelles, is sequestered into double-membrane vesicles and delivered …

Autophagy is a lysosomal degradative process which recycles cellular waste and eliminates
potentially toxic damaged organelles and protein aggregates. The important cytoprotective …

Autophagy is a process in which cytosol and organelles are sequestered within double-
membrane vesicles that deliver the contents to the lysosome/vacuole for degradation and …

Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora of
cellular processes, including responses to nutrient availability and composition, stress …