Topoisomerase I inhibitors constitute a new class of anti-cancer agents. Recently, topotecan
and irinotecan were registered for clinical use in ovarian cancer and colorectal cancer …

The topoisomerase I inhibitors reviewed in this paper are all semisynthetic analogs of
camptothecin (CPT). Modulation of this intranuclear enzyme translates clinically in to …

Drug delivery technologies represent a vast and vital area of Research and Development.
The demand for innovative drug delivery systems continues to grow, and this growth …

The power of radical reactions continues to increase! A cascade radical annulation route
now allows perhaps the mildest and most general method for the synthesis of both known …

Recently, cell membrane-derived nanoparticles, particularly of RBCs, have been explored
for delivery of hydrophilic solutes of varied size and complexities. So far, these naturally …

The solubility of camptothecin (CPT), a highly potent antineoplastic agent, as a function of
different concentrations of cyclodextrins (α-cyclodextrin, α-CD; β-cyclodextrin, β-CD; and γ …

Nanoparticles with longer blood circulation, high loading capacity, controlled release at the
targeted site, and preservation of camptothecin (CPT) in its lactone form are the key …

Background Preclinical studies comparing paclitaxel formulated with polyethoxylated castor
oil with the sonicated formulation of liposome-entrapped paclitaxel (LEP) have …

Purpose: To determine the inhibitory nature of sublethal doses of camptothecin (CPT) and
topotecan (TPT) treatments on normal human endothelial cells in vitro, as well as the in vivo …

BACKGROUND: Camptothecin (CPT) is a well-established topoisomerase I inhibitor against
a broad spectrum of cancers. However, poor aqueous solubility, instability, and toxic effects …