Anatomic pathology studies performed over 150 years ago revealed that excessive
activation of coagulation occurs in the setting of inflammation. However, it has taken over a …

The development of venous thromboembolism (VTE), which includes deep-vein thrombosis
and pulmonary embolism, may be associated with inherited or acquired risk factors that can …

Background Genetics plays an important role in venous thromboembolism (VTE). Factor V
Leiden (FVL or rs6025) and prothrombin gene G20210A (PT or rs1799963) are the genetic …

Background: Venous thromboembolism (VTE) is a common and potentially lethal disorder
that manifests mainly as deep vein thrombosis (DVT) of the extremities or pulmonary …

Objective—Previous studies have identified common genetic variants in 4 chromosomal
regions that together account for 14% to 15% of the variance in circulating levels of protein …

Background Rare coding mutations underlying deficiencies of antithrombin and proteins C
and S contribute to familial venous thromboembolism (VTE). It is uncertain whether rare …

Background The protein C (PC) anticoagulant system has a key role in maintaining
hemostatic balance. One missense (Ser219Gly) variant in the PC receptor (PROCR) was …

目的: 研发髙效, 准确, 简单, 实用的易栓症遗传性危险因素的基因检测方法,
用于我国易栓症患者的病因诊断和治疗指导. 方法: 收集上海交通大学医学院附属瑞金医院血栓 …

After carotid wire-injury, the mice deficient in endothelial Cxcr4 displayed significantly
increased neointima formation accompanied by more macrophages, reduced vascular …

Introduction When thrombin is bound to thrombomodulin (TM), it becomes a potent activator
of protein C (PC) and thrombin-activable fibrinolysis inhibitor (TAFI). Activation of PC is …