Analytical device miniaturization for the detection of circulating biomarkers

A Natalia, L Zhang, NR Sundah, Y Zhang… - Nature Reviews …, 2023 - nature.com
Diverse (sub) cellular materials are secreted by cells into the systemic circulation at different
stages of disease progression. These circulating biomarkers include whole cells, such as …

Programmable Nanostructures Based on Framework-DNA for Applications in Biosensing

B Liu, F Wang, J Chao - Sensors, 2023 - mdpi.com
DNA has been actively utilized as bricks to construct exquisite nanostructures due to their
unparalleled programmability. Particularly, nanostructures based on framework DNA (F …

Cascading CRISPR/Cas and Nanozyme for Enhanced Organic Photoelectrochemical Transistor Detection with Triple Signal Amplification

L Zhang, L Hou, HH Cai, B Sun, DM Han… - Analytical …, 2024 - ACS Publications
Innovative signal amplification and transduction play pivotal roles in bioanalysis. Herein,
cascading CRISPR/Cas and the nanozyme are integrated with electronic amplification in an …

Detection of SARS-CoV-2 RNA with a plasmonic chiral biosensor

Z Yu, L Pan, X Ma, T Li, F Wang, D Yang, M Li… - Biosensors and …, 2023 - Elsevier
The detection of SARS-CoV-2 infection is crucial for effective prevention and surveillance of
COVID-19. In this study, we report the development of a novel detection assay named …

Bidirectional linkage of DNA barcodes for the multiplexed mapping of higher-order protein interactions in cells

Y Liu, NR Sundah, NRY Ho, WX Shen, Y Xu… - Nature Biomedical …, 2024 - nature.com
Capturing the full complexity of the diverse hierarchical interactions in the protein
interactome is challenging. Here we report a DNA-barcoding method for the multiplexed …

Magnetic augmentation through multi-gradient coupling enables direct and programmable profiling of circulating biomarkers

Y Chen, L Zhang, X Wu, X Sun, NR Sundah… - Nature …, 2024 - nature.com
Conventional magnetic biosensing technologies have reduced analytical capacity for
magnetic field dimensionality and require extensive sample processing. To address these …

CoVSense: Ultrasensitive Nucleocapsid Antigen Immunosensor for Rapid Clinical Detection of Wildtype and Variant SARS‐CoV‐2

R Salahandish, JE Hyun, F Haghayegh… - Advanced …, 2023 - Wiley Online Library
The widespread accessibility of commercial/clinically‐viable electrochemical diagnostic
systems for rapid quantification of viral proteins demands translational/preclinical …

Protein-nucleic acid hybrid nanostructures for molecular diagnostic applications

NR Sundah, Y Seah, A Natalia, X Chen, P Cen, Y Liu… - Nano Research, 2024 - Springer
Molecular diagnostic technologies empower new clinical opportunities in precision
medicine. However, existing approaches face limitations with respect to performance …

Multiplexed RNA profiling by regenerative catalysis enables blood-based subtyping of brain tumors

Y Zhang, CY Wong, CZJ Lim, Q Chen, Z Yu… - Nature …, 2023 - nature.com
Current technologies to subtype glioblastoma (GBM), the most lethal brain tumor, require
highly invasive brain biopsies. Here, we develop a dedicated analytical platform to achieve …

DNA‐Mediated Control of Protein Function in Semi‐Synthetic Systems

DM Snider, S Pandit, ML Coffin, SB Ebrahimi… - …, 2022 - Wiley Online Library
The development of strategies for controlling protein function in a precise and predictable
manner has the potential to revolutionize catalysis, diagnostics, and medicine. In this regard …