Ecotropic viral integration site 1 (Evi1) was discovered in 1988 as a common site of
ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic …

The EVI1 oncogene at human chr 3q26 is rearranged and/or overexpressed in a subset of
acute myeloid leukemias and myelodysplasias. The EVI1 protein is a 135 kDa …

The formation of the craniofacial skeleton is a highly dynamic process that requires proper
orchestration of various cellular processes in cranial neural crest cell (cNCC) development …

MicroRNAs (miRNAs) are small non-coding RNA molecules that can negatively regulate
gene expression at the post-transcriptional level. miRNA expression patterns are regulated …

Enhanced expression of ecotropic viral integration site 1 (EVI-1) occurs in∼ 10% of acute
myeloid leukemia (AML) patients and is associated with a very poor disease outcome …

During the onset and progression of hematological malignancies, many changes occur in
cellular epigenome, such as hypo‐or hypermethylation of CpG islands in promoter regions …

It has been recently shown that DNA methyl transferase overexpression is correlated with
unfavourable prognosis in human malignancies while methylation deregulation remains a …

Despite frequent KRAS mutation, the early molecular mechanisms of pancreatic ductal
adenocarcinoma (PDAC) development have not been fully elucidated. By tracking a …

The overexpression of the ecotropic viral integration site-1 gene (EVI1/MECOM) marks the
most lethal acute myeloid leukemia (AML) subgroup carrying chromosome 3q26 …

The ecotropic viral integration site-1 gene (EVI1) encodes a zinc finger protein that functions
as a transcriptional regulator of hematopoietic stem cell self-renewal and long-term …