Abstract Purpose of Review The sense of smell is today one of the focuses of interest in
aging and neurodegenerative disease research. In several neurodegenerative diseases …

The gut–brain axis refers to the bidirectional communication between the enteric nervous
system and the central nervous system. Mounting evidence supports the premise that the …

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra. However, other non-dopaminergic neuronal systems such as the …

Amyotrophic lateral sclerosis (ALS) is a fatal disease, characterized by the degeneration of
both upper and lower motor neurons. Despite decades of research, we still to date lack a …

Abstract Changes in olfactory function are considered to be early biomarkers of Parkinson's
disease. Olfactory dysfunction is one of the earliest non-motor features of Parkinson's …

Background and purpose Rasagiline might be disease modifying in patients with
amyotrophic lateral sclerosis (ALS). The aim was to evaluate the effect of rasagiline 2 …

Background Recent research suggests that ayahuasca and its alkaloid-containing
ingredients may be helpful in the treatment and prevention of certain movement and …

Deficits in olfaction and taste are among the most frequent non-motor manifestations in
Parkinson's disease (PD) that start very early and frequently precede the PD motor …

Neuroinflammation plays a key role in the pathogenesis of epilepsy, but the underlying
mechanisms are not well understood. Mast cells are multifunctional immune cells that are …

Familial neurodegenerative diseases commonly involve mutations that result in either
aberrant proteins or dysfunctional components of the proteolytic machinery that act on …