Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …

The nuclear pore complex (NPC) is the massive protein assembly that regulates the
transport of macromolecules between the nucleus and the cytoplasm. Recent breakthroughs …

Genetic interactions between mutations and standing polymorphisms can cause mutations
to show distinct phenotypic effects in different individuals. To characterize the genetic …

Production of healthy gametes in meiosis relies on the quality control and proper distribution
of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age …

The nuclear pore complex (NPC) mediates nearly all exchanges between nucleus and
cytoplasm, and in many species, it changes composition as the organism ages. However …

Pho85 is a multifunctional CDK that signals to the cell when environmental conditions are
favorable. It has been connected to cell cycle control, mainly in Start where it promotes the …

Budding yeast cells produce a finite number of daughter cells before they die. Why old yeast
cells stop dividing and die is unclear. We found that age-induced accumulation of the G1/S …

Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-
effect relationships are not well understood. We show that most yeast cells arrest in G1 …

Under natural conditions, plants can be affected by several types of abiotic stresses, such as
flooding and the accumulation of toxic metals in the soil. Pb is a non-essential metallic …

In eukaryotic cells, the genetic material is segregated inside the nucleus. This
compartmentalization of the genome requires a transport system that allows cells to move …